How Chronic Kidney Disease (CKD) Develops?
Chronic kidney disease (CKD) is a progressive condition where the kidneys gradually lose their ability to filter waste products from the blood. The development of CKD can be influenced by various factors, including underlying health conditions, lifestyle choices, and genetic predisposition.
CKD increases the risk of additional health issues such as heart disease and stroke. The progression of CKD is typically gradual and often presents with minimal symptoms initially. To guide treatment decisions, CKD is categorized into five stages based on its severity.
Be cautious if you experience either of these common causes of CKD.
Diabetes
High blood sugar levels can damage the small blood vessels and filters in the kidneys, leading to kidney disease.
High blood pressure
Uncontrolled high blood pressure can put strain on the kidneys, causing damage over time
Other possible causes include:
- Glomerulonephritis (inflammation of the kidney’s filtering units).
- Polycystic kidney disease (an inherited disorder that causes cysts to grow in the kidneys).
- Repeated kidney infections or urinary tract infections.
- Kidney stones or blockages in the urinary tract.
- Extended use of certain medications
Protect Your Kidneys, Protect Your Life
Your kidneys work hard for you every day. Give them the care they deserve by knowing your eGFR
eGFR stands for estimated Glomerular Filtration Rate. eGFR is calculated from blood test results using a formula that looks at the level of creatinine (a waste product) in your blood. Results consistently below 60mL/min/1.73m2 indicate chronic kidney disease. eGFR can also be calculated by using the eGFR calculator below.
Estimated Glomerular Filtration Rate (eGFR) Calculator
eGFR: -- mL/min/1.73m²
| CKD Stage | eGFR Range (mL/min/1.73m²) | Description |
|---|---|---|
| Stage 1 | ≥ 90 | Normal or high eGFR |
| Stage 2 | 60 - 89 | Mildly decreased eGFR |
| Stage 3 | 30 - 59 | Moderately decreased eGFR |
| Stage 4 | 15 - 29 | Severely decreased eGFR |
| Stage 5 | < 15 | Kidney failure |
Note: This calculator uses the CKD-EPI formula for eGFR estimation. The results should be interpreted by a healthcare professional.
Seek advice from our expert if you suffers any of these symptoms.
Itchy and Dry Skin
More or less Often Urinating
Nausea & Fatigue
Loss of Appetite
Weight Loss Significantly
Foamy Urine
Managing CKD with Our Stem Cell Therapy
Chronic kidney disease (CKD) is a significant global health issue, and traditional treatments often fail to reverse its progression. Recent advances in stem cell therapy, particularly using mesenchymal stem cells (MSCs), have shown promise in treating CKD through various mechanisms.
How stem cell therapy may be your options?
Paracrine Effects
MSCs primarily exert their therapeutic effects through paracrine signaling. They release a variety of bioactive factors, including cytokines, growth factors, and extracellular vesicles, which help modulate the immune response, reduce inflammation, and promote tissue repair. This paracrine activity is crucial in protecting renal cells from apoptosis and reducing oxidative stress, which are common in CKD.
Immunomodulation
MSCs possess strong immunomodulatory properties. They can alter the local immune environment, reducing the activation of pro-inflammatory pathways. This helps in decreasing the inflammatory damage to renal tissues, which is a significant factor in the progression of CKD.
Anti-fibrotic Effects
In CKD, fibrosis is a major contributor to kidney dysfunction. MSCs can inhibit the processes that lead to fibrosis, thereby preserving kidney structure and function. They achieve this by modulating the activity of fibroblasts and reducing the deposition of extracellular matrix components.
Regeneration and Repair
MSCs have the ability to differentiate into various cell types, including renal tubular cells. This differentiation can contribute to the repair of damaged kidney tissues. Moreover, they can stimulate the proliferation of resident renal cells, enhancing the regeneration of renal structures.
Oxidative Stress Reduction
Oxidative stress plays a critical role in kidney injury. MSCs help mitigate oxidative stress by enhancing the antioxidant defenses in renal cells, thereby protecting them from damage and promoting survival.